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Childhood stress and adversity is associated with late-life dementia in Aboriginal Australians.

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dc.contributor.authorRadford K.
dc.contributor.authorDelbaere K.
dc.contributor.authorDraper B.
dc.contributor.authorMack H.A.
dc.contributor.authorDaylight G.
dc.contributor.authorCumming R.
dc.contributor.authorChalkley S.
dc.contributor.authorMinogue C.
dc.contributor.authorBroe G.A.
dc.date.accessioned2024-11-19T05:29:47Z
dc.date.available2024-11-19T05:29:47Z
dc.date.copyright2017
dc.date.issued2017-09-18en
dc.description.abstractObjectives: High rates of dementia have been observed in Aboriginal Australians. This study aimed to describe childhood stress in older Aboriginal Australians and to examine associations with late-life health and dementia. Design A cross-sectional study with a representative sample of community-dwelling older Aboriginal Australians. Setting Urban and regional communities in New South Wales, Australia. Participants 336 Aboriginal and/or Torres Strait Islander Australians aged 60-92 years, of whom 296 were included in the current analyses. Measurements Participants completed a life course survey of health, well-being, cognition, and social history including the Childhood Trauma Questionnaire (CTQ), with consensus diagnosis of dementia and Alzheimer disease. Results CTQ scores ranged from 25-117 (median: 29) and were associated with several adverse childhood indicators including separation from family, poor childhood health, frequent relocation, and growing up in a major city. Controlling for age, higher CTQ scores were associated with depression, anxiety, suicide attempt, dementia diagnosis, and, specifically, Alzheimer disease. The association between CTQ scores and dementia remained significant after controlling for depression and anxiety variables (OR: 1.61, 95% CI: 1.05-2.45). In contrast, there were no significant associations between CTQ scores and smoking, alcohol abuse, diabetes, or cardiovascular risk factors. Conclusions Childhood stress appears to have a significant impact on emotional health and dementia for older Aboriginal Australians. The ongoing effects of childhood stress need to be recognized as people grow older, particularly in terms of dementia prevention and care, as well as in populations with greater exposure to childhood adversity, such as Aboriginal Australians.Copyright © 2017 American Association for Geriatric Psychiatry
dc.description.grantNo: 1103312 Organisation: (NHMRC) National Health and Medical Research Council Organisation No: 501100000925 Country: Australia
dc.description.grantNo: 1105106 Organisation: (NHMRC) National Health and Medical Research Council Organisation No: 501100000925 Country: Australia
dc.description.grantNo: 510347 Organisation: (NHMRC) National Health and Medical Research Council Organisation No: 501100000925 Country: Australia
dc.identifier.citationAmerican Journal of Geriatric Psychiatry. Vol.25(10), 2017. pp. 1097-1106.
dc.identifier.doihttps://dx.doi.org/10.1016/j.jagp.2017.05.008
dc.identifier.institution(Radford, Delbaere, Draper, Mack, Daylight, Chalkley, Minogue, Broe) Neuroscience Research Australia, Sydney, NSW, Australia
dc.identifier.institution(Radford, Delbaere, Draper, Mack, Broe) Faculty of Medicine, University of New South Wales, Sydney, NSW, Australia
dc.identifier.institution(Cumming) School of Public Health, University of Sydney, Sydney, NSW, Australia
dc.identifier.pubmedid28689644 [https://www.ncbi.nlm.nih.gov/pubmed/?term=28689644]
dc.identifier.urihttps://lowitja.intersearch.com.au/handle/1/530
dc.relation.ispartofAmerican Journal of Geriatric Psychiatry
dc.subject.keywordsDementia
dc.subject.keywordsAdverse childhood experiences
dc.titleChildhood stress and adversity is associated with late-life dementia in Aboriginal Australians.
dc.typeArticle
dc.type.studyortrialObservational study (cohort, case-control, cross sectional, or survey)

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